Krishna (University of Sheffield)

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Greetings! My name is Krishna, and I am a third year student at the University of Sheffield. My PhD project involves the mechanistics of how viruses known as bacteriophages interact with the cell surface of Enterococcal bacteria. These bacteriophages specifically target bacteria living in the digestive systems of humans and animals. 

We particularly focus on how these viruses use a complex sugar structure on the bacterial surface called Enterococcal Polysaccharide Antigen (EPA) to achieve a successful infection. By understanding this, we would be able to synthetically engineer these bacteriophages that can target these bacteria, with the goal of treating Enterococcal infections in patients. Such fundamental studies are very important to achieve translational antibiotic alternative therapeutics, especially in the forthcoming uprising of Antimicrobial resistant (AMR) superbugs. 

I enjoy learning new science on a daily basis, whether from seminars, conferences, or reading recent publications. One exciting aspect of my project is implementing new techniques. While challenges are inevitable, it’s incredibly rewarding when a method works as hypothesised, reinforcing a first-principles understanding that is crucial for a PhD. Presenting to large audiences was initially challenging, but practice and growing expertise with my subject have made it much easier.

Applying to DiMeN is highly competitive, and being an international student in the mix does not make it any easier! I particularly focused on networking - reaching out to supervisors and their current group members to learn about the projects and wider programme. Reading the relevant literature and speaking with supervisors beforehand were crucial steps I recommend for a strong application. I also emphasised how my Masters research and clinical trial experience aligned with my future goals of pursuing a PhD and beyond in this field.