Kirsty: Newcastle University

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I'm Kirsty, a second year PhD student at Newcastle University.

My project is focused on creating drugs that are able to inhibit the Complement system (part of the body's immune system). Complement has been implicated in a range of diseases and my interest is in its role in neurodegenerative conditions such as Alzheimer's disease. Neuroinflammation in these diseases can be harmful rather than protective as the immune system is overactivated and damages the body's own cells. I am working to create specialised compounds that can cross into the brain and reduce inflammation. The first generation of these compounds have been tested and shown to inhibit part of the Complement system. I am working to strengthen this effect further and improve our understanding of how these compounds work. 

I really enjoy the variety of work this interdisciplinary project requires particularly the combination of chemistry and biology. It's been a great challenge to really delve into the theory of both disciplines and combine them together in practice.

I think the most interesting thing about my project is its originality. Many neurodegenerative conditions are currently untreatable so being able to work on a project to change that is really rewarding. Treating neurodegenerative conditions by targeting the immune system is starting to become a hot topic in the field and it has been great to be involved in helping to push this research area forward. This is also what makes the project really challenging as there is no precedent and much we don't yet know. A lot of perseverance is needed for all the dead ends and setbacks that come with novel work.

Before starting my PhD I chose to work in industry for a few years which gave me lots of experience and helped my application stand out. This really helped at the interview too as I had lots of examples to draw from.  Not everyone has industry experience but the skills developed in any position are largely translational and show your potential.  Before I applied I also did quite a bit of homework into both the project and the group I would be joining. It's really important to make sure that not only the research but the people you'll be working with are a good fit for you. The group environment and their culture are a big part of the PhD experience and it is key to ensure this (along with the project itself) is where you want to dedicate the next four years.