Available Projects

Hatton, C.F., Botting, R.A., Dueñas, M.E. et al. Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2. Nat Commun 12, 7092 (2021). https://doi.org/10.1038/s41467-021-27318-0 Rutherford HA, Kasher PR, Hamilton N. Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy. Front Immunol. (2021);11:623650. doi: 10.3389/fimmu.2020.623650. Yang C, Georgiou M, Atkinson R, Collin J, Al-Aama J, Nagaraja-Grellscheid S, Johnson C, Ali R, Armstrong L, Mozaffari-Jovin S, Lako M. Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond. Front Cell Dev Biol. 2021 Jul 28;9:700276. doi: 10.3389/fcell.2021.700276 Lennie, E., Tsoumpas, C. & Sourbron, S. Multimodal phantoms for clinical PET/MRI. EJNMMI Phys 8, 62 (2021). https://doi.org/10.1186/s40658-021-00408-0 Solis-Castro Oscar O., Wong Natalie, Boissonade Fiona M. Chemokines and Pain in the Trigeminal System. Front. Pain Res., 2021 July; 2:31 DOI: https://doi.org/10.3389/fpain.2021.689314 Hammond S, Olsson-Brown A, Gardner J, Thomson P, Ali SE, Jolly C, Carr D, Ressel L, Pirmohamed M, Naisbitt D. T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. J Immunother Cancer. 2021 May;9(5):e002521. doi: 10.1136/jitc-2021-002521. Varn, F., Johnson, K., Barthel, F., Kim, H., Wade, T., Malta, T., Sabedot, T., Lodha, D., Ajaib, S., Ahmed, N., Garofano, L., D’Angelo, F., Stead, L., Poisson, L., Noushmehr, H., Iavarone, A., Verhaak, R., & GLASS Consortium (2021). OMRT-3. Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment. Neuro-oncology Advances, 3 (Suppl 2), ii7–ii8. https://doi.org/10.1093/noajnl/vdab070.029 Varn, F., Johnson, K., Barthel, F., Kim, H., Wade, T., Lodha, D., Ajaib, S., Ahmed, N., Garofano, L., D'Angelo, F., Stead, L., Noushmehr, H., Varone, A. and Verhaak, R. (2020). EPCO-08. TUMOR-IMMUNE INTERACTIONS ARE DYNAMIC AND INFLUENCE THE EVOLUTIONARY TRAJECTORY OF ADULT DIFFUSE GLIOMA. Neuro-Oncology. 22. ii70-ii71. DOI: https://doi.org/10.1093/neuonc/noaa215.287 George E. Stenhouse, Khuzwayo C. Jere, Chikondi Peno, Rebecca J. Bengtsson, End Chinyama, Jonathan Mandolo, Amy Cain, Miren Iturriza-Gómara, Naor Bar-Zeev, Nigel A. Cunliffe, Jennifer Cornick and Kate S. Baker (2021) Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance Microbial Genomics;7:000532 DOI 10.1099/mgen.0.000532 Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury. FASEB J. 2021 May;35(5):e21604. doi: 10.1096/fj.202100240R Jonathon Alexis Coates, Elliot Brooks, Amy Louise Brittle, Emma Louise Armitage, Martin Peter Zeidler, Iwan Robert Evans, 'Identification of functionally distinct macrophage subpopulations in Drosophila' eLife doi: 10.7554/eLife.58686 Joshua A. F. Sutton, Oliver T. Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F. Gibson, Eric J. G. Pollitt, Simone C. Tazoll, William Turnbull, Natalia H. Hajdamowicz, Bartłomiej Salamaga, Grace R. Pidwill, Alison M. Condliffe, Stephen A. Renshaw, Waldemar Vollmer, Simon J. Foster. Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. Plos Pathogens doi: 10.1371/journal.ppat.1009468 Clancy,A, Heride,C. Pinto-Fernández,A., Elcocks,H., Kallinos,A., Kayser-Bricker,K.J., Wang, W., Smith,V., Davis,S., Fessler,S., McKinnon,C., Katz,M., Hammonds,T., Jones, N.P., O’Connell,J., Follows,B., Mischke,S., Caravella,J.A., Ioannidis,S., Dinsmore,C., Kim, S., Behrens,A., Komander,D., Kessler,B.M., Urbé,S, Clague,M.J. (2021) The deubiquitylase USP9X controls ribosomal stalling. J. Cell Biol. 220 (3): e202004211, doi: 10.1083/jcb.202004211 Olivier R. Tardy, Emma L. Armitage, Lynne R. Prince, Iwan R. Evans. The Epidermal Growth Factor Ligand Spitz Modulates Macrophage Efferocytosis, Wound Responses and Migration Dynamics During Drosophila Embryogenesis Front. Cell Dev. Biol. doi:10.3389/fcell.2021.636024 Mengoli V, Jonak K, Lyzak O, Lamb M, Lister LM, Lodge C, Rojas J, Zagoriy I, Herbert M, Zachariae W. Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension. EMBO J. 2021 Apr 1;40(7):e106812. DOI: 10.15252/embj.2020106812 Serat-E Ali as part of the COVID-LIV Study Group. Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BJM Open doi:10.1136/bmjopen-2020-048317 Snodgrass RO, Chico TJA, Arthur HM. Hereditary Haemorrhagic Telangiectasia, an Inherited Vascular Disorder in Need of Improved Evidence-Based Pharmaceutical Interventions. Genes (Basel). 2021 Jan 27;12(2):174. doi: 10.3390/genes12020174 Castanheira, C., Balaskas, P., Falls, C. et al. Equine synovial fluid small non-coding RNA signatures in early osteoarthritis. BMC Vet Res 17, 26 (2021). https://doi.org/10.1186/s12917-020-02707-7 Kreilkamp BAK, McKavanagh A, Alonazi B, Bryant L, Das K, Wieshmann UC, Marson AG, Taylor PN, Keller SS. Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance. Neuroimage Clin.2021;29:102564. doi: 10.1016/j.nicl.2021.102564. Ane Ogbe, Barbara Kronsteiner, Donal T. Skelly, Matthew Pace, Anthony Brown, Emily Adland, Kareena Adair, Hossain Delowar Akhter, Mohammad Ali, Serat-E Ali, Adrienn Angyal, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Helen Brown, Senthil Chinnakannan, Christopher Conlon, Catherine de Lara, Thushan de Silva, Christina Dold, Tao Dong, Timothy Donnison, David Eyre, Amy Flaxman, Helen Fletcher, Joshua Gardner, James T. Grist, Carl-Philipp Hackstein, Kanoot Jaruthamsophon, Katie Jeffery, Teresa Lambe, Lian Lee, Wenqin Li, Nicholas Lim, Philippa C. Matthews, Alexander J. Mentzer, Shona C. Moore, Dean J. Naisbitt, Monday Ogese, Graham Ogg, Peter Openshaw, Munir Pirmohamed, Andrew J. Pollard, Narayan Ramamurthy, Patpong Rongkard, Sarah Rowland-Jones, Oliver Sampson, Gavin Screaton, Alessandro Sette, Lizzie Stafford, Craig Thompson, Paul J. Thomson, Ryan Thwaites, Vinicius Vieira, Daniela Weiskopf, Panagiota Zacharopoulou, Oxford Immunology Network Covid-19 Response T Cell Consortium, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team, Lance Turtle, Paul Klenerman, Philip Goulder, John Frater, Eleanor Barnes & Susanna Dunachie (2021) T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses Nature Communications doi:10.1038/s41467-021-21856-3 Lorna Bryant, Emilie T. McKinnon, James A. Taylor, Jens H. Jensen, Leonardo Bonilha, Christophe de Bezenac, Barbara A. K. Kreilkamp, Guleed Adan, Udo C. Wieshmann, Shubhabrata Biswas, Anthony G. Marson, Simon S. Keller. Fiber ball white matter modeling in focal epilepsy Human Brain Mapping doi: 10.1002/hbm.25382 Adam Albanese, Leonard A. Daly, Daniela Mennerich, Thomas Kietzmann, Violaine Sée. The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity Int. J. Mol. Sci. 2021, 22(1), 268; https://doi.org/10.3390/ijms22010268

Mawdesley A, Davidson L, Anjum S, Kirby J, Tyson-Capper A (2020) Effect of Cobalt Ions on Chemokine Expression: Case Report of Immune Cell Infiltration in Patient Undergoing Revision of Metal-On-Metal Implant. J Orthop Res Ther 5: 1154. DOI: 10.29011/2575-8241.001154 Adam J. Carlton, Julia Halford, Anna Underhill, Jing‐Yi Jeng, Matthew R. Avenarius, Merle L. Gilbert, Federico Ceriani , Kimimuepigha Ebisine, Steve D. M. Brown, Michael R. Bowl, Peter G. Barr‐Gillespie & Walter Marcotti. Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. J Physiol 599.4 (2021) pp 1173–1198 https://doi.org/10.1113/JP280670 Florian Gothe, Catherine F Hatton, Linh Truong, Zofia Klimova, Veronika Kanderova, Martina Fejtkova, Angela Grainger, Venetia Bigley, Joanna Perthen, Dipayan Mitra, Ales Janda, Eva Fronkova, Dusana Moravcikova, Sophie Hambleton, Christopher J A Duncan. A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis. Clinical Infectious Diseases, ciaa1790, https://doi.org/10.1093/cid/ciaa1790 Stephen R Knight, Antonia Ho, Riinu Pius, Iain Buchan, Gail Carson, Thomas M Drake, Jake Dunning, Cameron J Fairfield, Carrol Gamble, Christopher A Green, Rishi Gupta, Sophie Halpin, Hayley E Hardwick, Karl A Holden, Peter W Horby, Clare Jackson, Kenneth A Mclean, Laura Merson, Jonathan S Nguyen-Van-Tam, Lisa Norman, Mahdad Noursadeghi, Piero L Olliaro, Mark G Pritchard, Clark D Russell, Catherine A Shaw, Aziz Sheikh, Tom Solomon, Cathie Sudlow, Olivia V Swann, Lance CW Turtle, Peter JM Openshaw, Kenneth Baillie, Malcolm G Semple, Annemarie B Docherty, Ewen M Harrison, on behalf of the ISARIC4C investigators Including Robyn Kiy & Rebekah Penrice-Randal (2020) Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m3339 Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom & Laura C. Greaves ‘Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis’ – ‘Nature Cancer’ doi:10.1038/s43018-020-00112-5 Lodge C, Herbert M. Oocyte aneuploidy-more tools to tackle an old problem. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):11850-11852 DOI: 10.1073/pnas.2005739117 Pei G. Chew, Peter P. Swoboda, Carrie Ferguson, Pankaj Garg, Abigail L. Cook, Said Ibeggazene, Louise A. E. Brown, Thomas P. Craven, James R. Foley, Graham J. Fent, Christopher E. Saunderson, David M. Higgins, Sven Plein, Karen M. Birch, John P. Greenwood ‘Feasibility and reproducibility of a cardiovascular magnetic resonance free-breathing, multi-shot, navigated image acquisition technique for ventricular volume quantification during continuous exercise. QIMS doi: 10.21037/qims-20-117 David A. Dorward, Clark D. Russell, In Hwa Um, Mustafa Elshani, Stuart D. Armstrong, Rebekah Penrice-Randal, Tracey Millar, Chris E. B. Lerpiniere, Giulia Tagliavini, Catherine S. Hartley, Nadine P. Randle, Naomi N. Gachanja, Philippe M. D. Potey, Xiaofeng Dong, Alison M. Anderson, Victoria L. Campbell, Alasdair J. Duguid, Wael Al Qsous, Ralph BouHaidar, J. Kenneth Baillie, Kevin Dhaliwal, William A. Wallace, Christopher O. C. Bellamy, Sandrine Prost, Colin Smith, Julian A. Hiscox, David J. Harrison, Christopher D. Lucas ‘Tissue-Specific Immunopathology in Fatal COVID-19’ – ‘American Journal of Respiratory and Critical Care Medicine’ doi: 10.1164/rccm.202008-3265OC Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. Caisey V. Pulford, Blanca M. Perez-Sepulveda, Rocío Canals, Jessica A. Bevington, Rebecca J. Bengtsson, Nicolas Wenner, Ella V. Rodwell, Benjamin Kumwenda, Xiaojun Zhu, Rebecca J. Bennett, George E. Stenhouse, P. Malaka De Silva, Hermione J. Webster, Jose A. Bengoechea, Amy Dumigan, Alicia Tran-Dien, Reenesh Prakash, Happy C. Banda, Lovemore Alufandika, Mike P. Mautanga, Arthur Bowers-Barnard, Alexandra Y. Beliavskaia, Alexander V. Predeus, Will P. M. Rowe, Alistair C. Darby, Neil Hall, François-Xavier Weill, Melita A. Gordon, Nicholas A. Feasey, Kate S. Baker, Jay C. D. Hinton ‘Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa’ – ‘Nature Microbiology’ doi: 10.1038/s41564-020-00836-1 Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong,1, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod ‘Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites’ – ‘Front Cell Infect Microbiol’ doi: 10.3389/fcimb.2020.00203 Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randalld, Daniel Erskine, Christopheer M.Morris, Amy K.Reeve, Gavin J.Clowry, Fiona E.N. LeBeaua‘Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein’ – Neurobiology of Disease doi: 10.1016/j.nbd.2020.105226 George E. Stenhouse, Khuzwayo C. Jere, Chikondi Peno, Rebecca J. Bengtsson, End Chinyama, Jonathan Mandolo, K. Cain, Miren Iturriza-Gómara, Naor Bar-Zeev, Nigel A. Cunliffe, Jennifer Cornick, Kate S. Baker 'Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance. bioRxiv 2020 doi: https://doi.org/10.1101/2020.11.20.391235 Mandy J. Peffers, Alzbeta Chabronova, Panagiotis Balaskas, Yongxiang Fang, Philip Dyer, Andy Cremers, Pieter J. Emans, Peter Z. Feczko, Marjolein M. Caron & Tim J. M. Welting SnoRNA signatures in cartilage ageing and osteoarthritis. Scientific Reports doi: 10.1038/s41598-020-67446-z Panagiotis Balaskas, Jonathan A. Green, Tariq M. Haqqi, Philip Dyer, Yalda A. Kharaz, Yongxiang Fang, Xuan Liu, Tim J.M. Welting, Mandy J. Peffers, ‘Small Non-Coding RNAome of Ageing Chondrocytes’ – ‘Int. J. Mol. Sci’ doi:10.3390/ijms21165675 Shona C. Moore, Rebekah Penrice-Randal, Muhannad Alruwaili, Nadine Randle, Stuart Armstrong, Catherine Hartley, Sam Haldenby, Xiaofeng Dong, Abdulrahman Alrezaihi, Mai Almsaud, Eleanor Bentley, Jordan Clark, Isabel García-Dorival, Paul Gilmore, Ximeng Han, Benjamin Jones, Lisa Luu, Parul Sharma, Ghada Shawli, Yani Sun, Qin Zhao, Steven T. Pullan, Daniel P. Carter, Kevin Bewley, Jake Dunning, En-min Zhou, Tom Solomon, Michael Beadsworth, James Cruise, Derrick W. Crook, David A. Matthews, Andrew D. Davidson, Zana Mahmood, Waleed Aljabr, Julian Druce, Richard Vipond, Lisa Ng, Laurent Renia, Peter J. M. Openshaw, J. Kenneth Baillie, Miles W. Carroll, James Stewart, Alistair Darby, Malcolm Semple, Lance Turtle, Julian A. Hiscox ‘Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism’ – ‘Viruses’ doi: 10.3390/v12101164 Adam J Carlton, Julia Halford, Anna Underhill, Jing-Yi Jeng, Matthew R Avenarius, Merle L Gilbert, Federico Ceriani, Kimimuepigha Ebisine, Steve D M Brown, Michael R Bowl, Peter G Barr-Gillespie, Walter Marcotti Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness – ‘J Physiol’ doi: 10.1113/JP280670 Philip AJ Crosbie, Rhian Gabe, Irene Simmonds, Martyn Kennedy, Suzanne Rogerson, Nazia Ahmed, David R Baldwin, Richard Booton, Ann Cochrane, Michael Darby, Kevin Franks, Sebastian Hinde, Sam M Janes, Una Macleod, Mike Messenger, Henrik Moller, Rachael L Murray, Richard D Neal, Samantha L Quaife, Mark Sculpher, Puvanendran Tharmanathan, David Torgerson, Matthew EJ Callister 'Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk' 'BMJ Open' doi: 10.1136/bmjopen-2020-037075 Alexander G. Bury, Amy E. Vincent, Doug M. Turnbull, Paolo Actis, Gavin Hudson (2020) Mitochondrial isolation: when size matters – ‘Wellcome Open Res’ doi: https://doi.org/10.12688/wellcomeopenres.16300.2 Phillippa J Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, Wenbin Wei, Chris Hastings, Siew Wong, Christine Lo, Samuel Evetts, Hannah Clemmens, Matthew Wyles, Sam Willcox, Thomas Payne, Rachel Hughes, Laura Ferraiuolo, Caleb Webber, Winston Hide, Richard Wade-Martins, Kevin Talbot, Michele T Hu, Oliver Bandmann 'Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease' – ‘Prog Neurobiol’ doi: 10.1016/j.pneurobio.2020.101772 Elisa Molinari, Shalabh Srivastava, Rebecca M. Dewhurst, John A. Sayer 'Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles' – ‘BMC Nephrology’ doi:10.1186/s12882-020-02094-z. Grace Mallett, Warren Patterson, Megan Payne, Shoba Amarnath 'Isolation and Characterization of Innate Lymphoid Cells within the Murine Tumor Microenvironment' – ‘MIMB, volume 2121’ doi: 10.1007/978-1-0716-0338-3_14 Madeleine R. Brown, Sheena E. Radford, Eric W. Hewitt 'Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection' – ‘Frontiers in Molecular Neuroscience’ doi: 10.3389/fnmol.2020.609073 Andrea C Masi, Yaa E A Oppong, Beate Haugk, Christopher A Lamb, Linda Sharp, James M Shaw, Christopher J Stewart, Kofi W Oppong 'Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) formalin fixed paraffin-embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis' -'Gut' doi:10.1136/gutjnl-2020-322457 James C. Waddington, Serat-E Ali, Sophie L. Penman, Paul Whitaker, Jane Hamlett, Amy Chadwick, Dean J. Naisbitt, B. Kevin Park, Xiaoli Meng 'Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury' - 'Chemical Research in Toxicology' doi:10.1021/acs.chemrestox.0c00400 Alexander G. Bury, Amy E. Vincent, Doug M. Turnbull, Paolo Actis, Gavin Hudson 'Mitochondrial Isolation: when size matters' - 'Wellcome Open Research' doi:10.12688/wellcomeopenres.16300.1 Katherine A. Davies, Benjamin Chadwick, Roger Hewson, Juan Fontana, Jamel Mankouri, John N. Barr 'The RNA Replication Site of Tula Orthohantavirus Resides within a Remodelled Golgi Network' - 'Cells' doi:10.3390/cells9071569 Viralkumar V. Panchal, Caitlin Griffiths, Hamed Mosaei, Bohdan Bilyk, Joshua A. F. Sutton, Oliver T. Carnell, David P. Hornby, Jeffrey Green, Jamie K. Hobbs, William L. Kelley, Nikolay Zenkin, Simon J. Foster - 'Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression' - 'Plos Pathogens' doi:10.1371/journal.ppat.1008672 Rebecca Marie Dewhurst, Annachiara Scalzone, Joseph Buckley, Clara Mattu, Kenneth S. Rankin, Piergiorgio Gentile, Ana Marina Ferreira 'Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release' -'Front. Bioeng. Biotechnol.' doi :10.3389/fbioe.2020.00754 Thomas M.D. Sheard, Luke Howlett, Hannah Kirton, Zhaokang Yang, Georgina Gurrola, Derek Steele, Izzy Jayasinghe, Hector H. Valdivia, John Colyer 'Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes' - 'bioRxiv - Preprint Server for Biology': doi: 10.1101/2020.06.26.131854 Catherine M. Buckley, Henderikus Pots, Aurelie Gueho, James H. Vines, Christopher J. Munn, Ben A. Phillips, Bernd Gilsbach, David Traynor, Anton Nikolaev, Thierry Soldati, Andrew J. Parnell, Arjan Kortholt, and Jason S. King 'Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria' - 'Current Biology': doi:https://doi.org/10.1016/j.cub.2020.05.049 Bartoli, F., Bailey, M. A., Rode, B., Mateo, P., Antigny, F., Bedouet, K., Gerbaud, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Ainscough, J. F. X., Kearney, M. T., Bruns, A.-F., Shi, J., Appleby, H. L., Young, R. S., Shawer, H. M., Debant, M., Gomez, A.-M., Beech, D. J., Foster, R., Benitah, J.-P. and Sabourin, J. (2020) ‘Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload’, 'Circulation'. doi: 10.1161/CIRCULATIONAHA.118.038891. Devlin, L. A., Ramsbottom, S. A., Overman, L. M., Lisgo, S. N., Clowry, G., Molinari, E., Powell, L., Miles, C. G. and Sayer, J. A. (2020) ‘Embryonic and foetal expression patterns of the ciliopathy gene CEP164’ - 'PLOS ONE' doi: 10.1371/journal.pone.0221914. Matthew J. Burke, Peter G. Stockley, and Joan Boyes. 'Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?' - 'Viruses' doi: 10.3390/v12040473 Andrea C Masi, Sara Koo, Christopher A Lamb ,Mark A Hull, Linda Sharp, Andrew Nelson, James S Hampton, Colin J Rees, Christopher J Stewart. 'Using faecal immunochemical test (FIT) undertaken in a national screening programme for large-scale gut microbiota analysis' - 'GUT' doi:10.1136/gutjnl-2020-321594

Lauren Tomlinson, Zhen Qi Lub, Robert A Bentley, Helen E.Colley, Craig Murdoch, Steven D.Webb, Michael J.Cross, Ian M. Copple, Parveen Sharmaa ‘Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway’ – ‘Biomedicine & Pharmacotherapy’ doi: 10.1016/j.biopha.2019.108637 Lauren J. Tomlinson, Alice K. M. Clubbs Coldron, Patrick A. Eyers, Claire E. Eyers ‘Determination of Phosphohistidine Stoichiometry in Histidine Kinases by Intact Mass Spectrometry’ – ‘MIMB, volume 2077’ doi: 10.1007/978-1-4939-9884-5_6 Lauren Tomlinson, Lauren Hyndman, James W. Firman, Robert Bentley, Jonathan A. Kyffin, Steven D. Webb, Sean McGinty, Parveen Sharma ‘In vitro Liver Zonation of Primary Rat Hepatocytes’ – ‘Front. Bioeng. Biotechnol’ doi: 10.3389/fbioe.2019.00017 Thomas M. D. Sheard, Sanjay R. Kharche, Christian Pinali, Holly A. Shiels ‘3D ultrastructural organisation of calcium release units in the avian sarcoplasmic reticulum’ – ‘Journal of Experimental Biology’ doi: 10.1242/jeb.197640 Molinari, E., Ramsbottom, S. A., Srivastava, S., Booth, P., Alkanderi, S., McLafferty, S. M., Devlin, L. A., White, K., Gunay-Aygun, M., Miles, C. G. and Sayer, J. A. 'Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts' – ‘Scientific Reports’ doi:10.1038/s41598-019-47243-z. Ajuwon, V., Ali, S.-E., Ashra, N., Banas, C., Barasa, S., Bhalla, S. R., Chakrabarty, A., Elelu, N., Ha, K. P., Ihekwaba, N., Mirza, N., Said, S., Sarmin, A., Sarveswaran, N., Simon, A. and Vallath, S. (2019) ‘Workforce Diversity: Let’s talk about race’ - eLife, 12 April. Available at: https://elifesciences.org/inside-elife/313036d9/workforce-diversity-let-s-talk-about-race. Ali, S.-E., Waddington, J. C., Park, B. K. and Meng, X. (2019) ‘Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury’ - 'Chemical Research in Toxicology' doi: 10.1021/acs.chemrestox.9b00275. Allen, S. P., Hall, B., Castelli, L. M., Francis, L., Woof, R., Siskos, A. P., Kouloura, E., Gray, E., Thompson, A. G., Talbot, K., Higginbottom, A., Myszczynska, M., Allen, C. F., Stopford, M. J., Hemingway, J., Bauer, C. S., Webster, C. P., De Vos, K. J., Turner, M. R., Keun, H. C., Hautbergue, G. M., Ferraiuolo, L. and Shaw, P. J. (2019) ‘Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis’ - 'Brain, 142' (3), pp. 586–605. doi: 10.1093/brain/awy353. Allen, S. P., Hall, B., Woof, R., Francis, L., Gatto, N., Shaw, A. C., Myszczynska, M., Hemingway, J., Coldicott, I., Willcock, A., Job, L., Hughes, R. M., Boschian, C., Bayatti, N., Heath, P. R., Bandmann, O., Mortiboys, H., Ferraiuolo, L. and Shaw, P. J. (2019) ‘C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis’ - 'Brain', 142 (12), pp. 3771–3790. doi: 10.1093/brain/awz302. Bennison, D. J., Irving, S. E. and Corrigan, R. M. (2019) ‘The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly’ - 'Cells, 8'(11), p. 1313. doi: 10.3390/cells8111313. da Silva, B., Irving, B. K., Polson, E. S., Droop, A., Griffiths, H. B. S., Mathew, R. K., Stead, L. F., Marrison, J., Williams, C., Williams, J., Short, S. C., Scarcia, M., O’Toole, P. J., Allison, S. J., Mavria, G. and Wurdak, H. (2019) ‘Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells’ - 'Journal of Cell Science, 132'(19). doi: 10.1242/jcs.228452. Devlin, L. A. and Sayer, J. A. ‘Renal ciliopathies’, Current Opinion in Genetics & Development. (Molecular and genetic basis of disease), 56, pp. 49–60. doi: 10.1016/j.gde.2019.07.005. Duncan, C. J. A., Thompson, B. J., Chen, R., Rice, G. I., Gothe, F., Young, D. F., Lovell, S. C., Shuttleworth, V. G., Brocklebank, V., Corner, B., Skelton, A. J., Bondet, V., Coxhead, J., Duffy, D., Fourrage, C., Livingston, J. H., Pavaine, J., Cheesman, E., Bitetti, S., Grainger, A., Acres, M., Innes, B. A., Mikulasova, A., Sun, R., Hussain, R., Wright, R., Wynn, R., Zarhrate, M., Zeef, L. A. H., Wood, K., Hughes, S. M., Harris, C. L., Engelhardt, K. R., Crow, Y. J., Randall, R. E., Kavanagh, D., Hambleton, S. and Briggs, T. A. (2019) ‘Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2’ - 'Science Immunology' doi: 10.1126/sciimmunol.aav7501. Duncan, J. A., Foster, R. and Kwok, J. C. F. (2019) ‘The potential of memory enhancement through modulation of perineuronal nets’ - 'British Journal of Pharmacology' 176(18), pp. 3611–3621. doi: 10.1111/bph.14672. Hatton, C. F. and Duncan, C. J. A. (2019) ‘Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis’ - 'Frontiers in Immunology' doi: 10.3389/fimmu.2019.02656. Mallett G, Laurence A and Amarnath S (2019) 'Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid cells' - 'International Journal of Molecular Sciences' doi: 10.3390/ijms20112836 Manners, O., Baquero-Perez, B. and Whitehouse, A. (2019) ‘m6A: Widespread regulatory control in virus replication’, Biochimica et Biophysica Acta (BBA)' - 'Gene Regulatory Mechanisms. (mRNA modifications in gene expression control)', 1862(3), pp. 370–381. doi: 10.1016/j.bbagrm.2018.10.015. Masi A.C., Stewart C.J. (2019) ‘The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis’ - 'Early Hum Dev' doi: 10.1016/j.earlhumdev.2019.104854 Miles, J., Scherz-Shouval, R. and van Oosten-Hawle, P. (2019) ‘Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response’ - 'Trends in Biochemical Sciences' doi: 10.1016/j.tibs.2019.06.009. Molinari, E., Ramsbottom, S. A., Srivastava, S., Booth, P., Alkanderi, S., McLafferty, S. M., Devlin, L. A., White, K., Gunay-Aygun, M., Miles, C. G. and Sayer, J. A. (2019) ‘Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts’ - 'Scientific Reports' doi: 10.1038/s41598-019-47243-z. Powell, L., Samarakoon, Y. H., Ismail, S. and Sayer, J. A. (2019) ‘ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses’, Small GTPases, 0(0), pp. 1–10. doi: 10.1080/21541248.2019.1703466. Ramsbottom, S. A., Thelwall, P. E., Wood, K. M., Clowry, G. J., Devlin, L. A., Silbermann, F., Spiewak, H. L., Shril, S., Molinari, E., Hildebrandt, F., Gunay-Aygun, M., Saunier, S., Cordell, H. J., Sayer, J. A. and Miles, C. G. 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Urszula L McClurg, Arash Nabbi, Charles Ricordel, Svitlana Korolchuk, Stuart McCracken, Rakesh Heer, Laura Wilson, Lisa M Butler, Bronwyn Kate Irving-Hooper, Rémy Pedeux, Craig N Robson, Karl T Riabowol & Olivier Binda Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein – ‘British Journal of Cancer’ doi:10.1038/bjc.2017.447 Adamson, K. I., Sheridan, E. and Grierson, A. J. (2018) ‘Use of zebrafish models to investigate rare human disease’, Journal of Medical Genetics, 55(10), pp. 641–649. doi: 10.1136/jmedgenet-2018-105358. Bansagi, B., Phan, V., Baker, M. R., O’sullivan, J., Jennings, M. J., Whittaker, R. G., Müller, J. S., Duff, J., Griffin, H. and Miller, J. A. (2018) ‘Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation’, Neurology, 90(21), pp. e1842–e1848. doi: 10.1212/WNL.0000000000005566. Bartoli, F., Bailey, M., Rode, B., Mateo, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Gomez, A. M., Beech, D., Foster, R., Benitah, J. P. and Sabourin, J. (2018) ‘Orai1 channels inhibition protects the heart from pressure overload-induced ventricular dysfunction’, Journal of Molecular and Cellular Cardiology. (SI:Abstracts ISHR-ES Amsterdam), 120, p. 12. doi: 10.1016/j.yjmcc.2018.05.046. Boczonadi, V., Jennings, M. J. and Horvath, R. (2018) ‘The role of tRNA synthetases in neurological and neuromuscular disorders’, FEBS Letters, 592(5), pp. 703–717. doi: 10.1002/1873-3468.12962. Juneja, M., Azmi, A., Baets, J., Roos, A., Jennings, M. J., Saveri, P., Pisciotta, C., Bernard-Marissal, N., Schneider, B. L., Verfaillie, C., Chrast, R., Seeman, P., Hahn, A. F., Jonghe, P. de, Maudsley, S., Horvath, R., Pareyson, D. and Timmerman, V. (2018) ‘PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease’, Journal of Neurology, Neurosurgery & Psychiatry, 89(8), pp. 870–878. doi: 10.1136/jnnp-2017-317562. Manners, O., Murphy, J. C., Coleman, A., Hughes, D. J. and Whitehouse, A. (2018)‘Contribution of the KSHV and EBV lytic cycles to tumourigenesis’, Current Opinion in Virology. (Engineering for viral resistance - Viruses and cancer), 32, pp. 60–70. doi: 10.1016/j.coviro.2018.08.014. Muniyandi, S., Pangratiou, G., Edwards, T. A. and Barr, J. N. (2018) ‘Structure and Function of the Human Respiratory Syncytial Virus M2–1 Protein’, in Harris, J. R. and Bhella, D. (eds) Virus Protein and Nucleoprotein Complexes. Singapore: Springer (Subcellular Biochemistry), pp. 245–260. doi: 10.1007/978-981-10-8456-0_11. Peffers, M. J., Balaskas, P. and Smagul, A. (2018) ‘Osteoarthritis year in review 2017: genetics and epigenetics’, Osteoarthritis and Cartilage, 26(3), pp. 304–311. doi: 10.1016/j.joca.2017.09.009. Ramsbottom, S. A., Molinari, E., Srivastava, S., Silberman, F., Henry, C., Alkanderi, S., Devlin, L. A., White, K., Steel, D. H., Saunier, S., Miles, C. G. and Sayer, J. A. (2018) ‘Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model’, Proceedings of the National Academy of Sciences, 115(49), pp. 12489–12494. doi: 10.1073/pnas.1809432115. Rubaiy, H. N., Ludlow, M. J., Siems, K., Norman, K., Foster, R., Wolf, D., Beutler, J. A. and Beech, D. J. (2018) ‘Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels’, British Journal of Pharmacology, 175(16), pp. 3361–3368. doi: 10.1111/bph.14379. Selvaraj, M., Yegambaram, K., Todd, E. J. A. A., Richard, C.-A., Dods, R. L., Pangratiou, G. M., Trinh, C. H., Moul, S. L., Murphy, J. C., Mankouri, J., Éléouët, J.-F., Barr, J. N. and Edwards, T. A. (2018) ‘The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex’, mBio, 9(6). doi: 10.1128/mBio.01554-18. Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F A, Liniany L P, Knight D, Samsel L A, Berlinguer-Palmini R, Yim J J , Felizardo T C, Eckhaus M A, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler D H, Van Kasteren S I, Laurence A, Bogyo M, Watts C, Shevach E M and Amarnath S (2018) 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T cells' Immunity 49 (2) 247-263 ; doi: 10.1016/j.immuni.2018.05.006 ​

Allen, C. F., Shaw, P. J. and Ferraiuolo, L. (2017) ‘Can Astrocytes Be a Target for Precision Medicine?’, in El-Khamisy, S. (ed.) Personalised Medicine: Lessons from Neurodegeneration to Cancer. Cham: Springer International Publishing (Advances in Experimental Medicine and Biology), pp. 111–128. doi: 10.1007/978-3-319-60733-7_7. Balaskas, P., Goljanek-Whysall, K., Clegg, P., Fang, Y., Cremers, A., Emans, P., Welting, T. and Peffers, M. (2017) 'MicroRNA Profiling in Cartilage Ageing', International Journal of Genomics. doi: 10.1155/2017/2713725. Feng, S., Bowden, N., Fragiadaki, M., Souilhol, C., Hsiao, S., Mahmoud, M., Allen, S., Pirri, D., Ayllon Tardajos, B., Akhtar, S., Thompson, A. A. R., Jo, H., Weber, C., Ridger, V., Schober, A. and Evans, P. C. (2017) ‘Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites’, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), pp. 2087–2101. doi: 10.1161/ATVBAHA.117.309249. Marsh, S. A., Arthur, H. M. and Spyridopoulos, I. (2017) ‘The secret life of nonclassical monocytes’, Cytometry Part A, 91(11), pp. 1055–1058. doi: https://doi.org/10.1002/cyto.a.23280 Gleeson, P. J., Wilson, V., Cox, T. E., Sharma, S. D., Smith-Jackson, K., Strain, L., Lappin, D., McHale, T., Kavanagh, D. and Goodship, T. H. J. (2016) ‘Chromosomal rearrangement—A rare cause of complement factor I associated atypical haemolytic uraemic syndrome’, Immunobiology. (SI: XXVI ICW Kanazawa 2016), 221(10), pp. 1124–1130. doi: 10.1016/j.imbio.2016.05.002. Lawrence, H., Deehan, D. J., Holland, J. P., Anjum, S. A., Mawdesley, A. E., Kirby, J. A. and Tyson-Capper, A. J. (2016) ‘Cobalt ions recruit inflammatory cells in vitro through human Toll-like receptor 4’, Biochemistry and Biophysics Reports, 7, pp. 374–378. doi: 10.1016/j.bbrep.2016.07.003. Lawrence, H., Mawdesley, A. E., Holland, J. P., Kirby, J. A., Deehan, D. J. and Tyson-Capper, A. J. (2016) ‘Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation’, Oncotarget, 7(7), pp. 7578–7585. doi: 10.18632/oncotarget.7105.

iCASE_2025_01: Precision Diabetic Medicine: Using the lipidome to optimize exercise as a therapeutic strategy in the ageing diabetes patient (Prof Lee Roberts) iCASE_2025_12: Novel multi-ion therapeutics to reverse early dental caries and improve oral health (Prof Maisoon Al-Jawad) iCASE_2025_09: Applying cutting-edge machine learning to rectal cancer MRI from a tertiary hospital: predicting treatment effect for chemoradiotherapy and immunotherapy (Dr Samuel Relton) iCASE_2025_25: The devil is in the details: exploiting biased receptor signalling to instruct development of precision oncology drugs (Dr Natalia A. Riobo-Del Galdo) Standard_2025_161: Identification of cellular receptors for bunyaviruses, a group of emerging haemorrhagic fever viruses (Dr John Barr) Standard_2025_189: Seeing inside the Parkinson’s disease brain by in situ cryo-ET (Dr Rene Frank) Standard_2025_147: Developing Small-Molecule Therapeutics for Recurrent, Therapy-Resistant Brain Cancer (Dr Robin Bon) Standard_2025_207: Developing the next generation of glycopeptide antibiotics (Dr Ryan Seipke) Standard_2025_121: Multiplexed infection biomarker detection with a single molecule biosensor (Prof Christoph Wälti) Standard_2025_139: Biological mechanisms underlying the frailest of patients with peripheral arterial disease (Dr Scott Bowen) Standard_2025_157: Revealing the molecular basis for differences in radiotherapy response and survival in HPV positive and HPV negative anal cancers (Prof Andrew MacDonald) Standard_2025_155: Modulation of neural extracellular matrix to improve frailty during ageing (Dr Jessica Kwok) Standard_2025_216: Uncovering the function of novel, neuronal, long non-coding RNA derived, micropeptides and their contribution to brain cancers (Dr Julie Aspden) Standard_2025_184: Using AI to predict amyloid aggregation in neurodegenerative diseases (Prof David Brockwell) Standard_2025_148: Primary Cilia Manipulation to Combat Systemic Fibrosis (Dr Rebecca Ross) Standard_2025_63: Understanding how phytochemicals exert anti-cancer effects with chemical proteomics (Dr James Thorne) Standard_2025_130: Investigating α-synuclein aggregation in microglia using human microglia transplanted into the mouse brain and cryo-electron microscopy (Dr Marine Krzisch) Standard_2025_166: Establishing the link between extracellular vesicles, maternal cardiac dysfunction and offspring cardiovascular health in pregnancies complicated by maternal diabetes (Dr Karen Forbes)

Standard_2025_158: Migration of Pseudomonas aeruginosa towards antibiotics: mechanisms and consequences (Dr Jamie Wheeler) iCASE_2025_07: Characterization of immunological responses in patients with liver cancer to predict immunotherapy efficacy and immune-related adverse events (Dr Xiaoli Meng) iCASE_2025_23: Exploring the anti-fibrotic activity and underlying molecular mechanisms of targeted compounds in patient derived models of Dupuytren’ disease and cancer (Dr Elizabeth Laird) iCASE_2025_10: Role of phosphodiesterases (PDEs) in atrial IP3 signaling and exploring the potential of utilizing them as therapies for atrial fibrillation (Dr Rebecca Burton) Standard_2025_195: Regulation of transcription replication conflicts in ca ncer: mechanism and functional implications in acute myeloid leukemia. (Dr Manolis Papamichos Chronakis) Standard_2025_58: Development of a biocompatible and bioabsorbable auxetic metamaterial for bone fixation (Dr Rosti Readioff) Standard_2025_205: Identification of Accessible Biomarkers Reflecting NRF2 Modulation in Humans (Prof Ian Copple) Standard_2025_45: Understanding how diabetes affects retinal cell crosstalk (Prof Reinhold Medina) Standard_2025_64: Decoding Shank3: New Insights into neuronal maintenance and neurodegeneration via structural analysis and Drosophila models (Dr Igor Barsukov) Standard_2025_208: Signalling systems in Pseudomonas: understanding new routes to prevent Pseudomonas aeruginosa adaptation (Prof Jo Fothergill) Standard_2025_99: Mitochondrial quality control for a healthy brain (Prof Michael Clague) Standard_2025_26: Cracking the Mitochondrial Code: New Frontiers in Tackling Linezolid Toxicity for Multi-Drug Resistant Tuberculosis (Dr Amy Chadwick) Standard_2025_60: Dissecting diversity of complement component 8-binding cell surface proteins to enhance leptospiral vaccine efficacy (Prof Nicholas Evans) iCASE_2025_16: Cardiovascular function around the clock: harnessing protective circadian mechanisms towards smarter design of novel retinoid therapies and lifestyle interventions (Dr Vanja Pekovic-Vaughan) iCASE_2025_17: Therapeutics for Middle Eastern Respiratory Syndrome (Prof James Stewart) iCASE_2025_02: A novel theragnostic approach for treating brain tumours (Prof Harish Poptani) Standard_2025_193: Bioengineering a protein nanocage as a novel drug and antigen vaccine delivery nanoplatform for cancer therapeutics (Prof Luning Liu) Standard_2025_153: Understanding skeletal tissue responses to sex and menopause in osteoarthritis (Dr Blandine Poulet) Standard_2025_127: Understanding the mechanisms of norovirus replication (Dr Edward Emmot) Standard_2025_163: Ageing-related susceptibility to pneumococcal pneumonia (Prof Aras Kadioglu) Standard_2025_219: The Biting-Edge of AI – Predicting Mosquito Vector Competence for Arboviruses (Dr Marcus Blagrove) Standard_2025_25: Uncovering the molecular mechanisms underpinning A. baumannii virulence (Dr Christopher Harding) Standard_2025_56: Un veiling novel interactions between the human complement system and pathogenic Neisseria (Dr Hayley Lavender) Standard_2025_71: Widening the ‘NET’ to identify new treatments for bronchiectasis (Dr Helen Wright)

iCASE_2025_15: Improving risk-directed treatment stratification for patients with rarer cancers (Dr Sarra Ryan) iCASE_2025_21: Chemical and structural biology tools to mimic frataxin function in iron-sulphur cluster biosynthesis (Prof Wyatt Yue) iCASE_2025_26: Investigating how ageing and anti-fungal resistance affect host-pathogen interactions in a C. elegans model of fungal infection (Dr Elizabeth Veal) Standard_2025_50: Unlocking the tumour glyco-code to transform the diagnosis and treatment of breast and prostate cancer (Dr Jennifer Munkley) Standard_2025_136: Unravelling how human milk bioactive components modulate the infant gut microbiome (Prof Christopher Stewart) Standard_2025_79: Investigating the role of novel motor protein in tendon development and aging (Dr Katarzyna Pirog) Standard_2025_91: In vivo modelling to develop novel therapies against neurocognitive deficits in childhood cancer survivors (Dr Debbie Hicks) Standard_2025_173: Metabolic barcoding of microbial antibiotic exposomes (Dr Katherine Duncan) Standard_2025_105: Macrophage reprogramming in response to the clearance of pathogen-induced cell death (Prof Matthias Trost) Standard_2025_59: Mitonuclear Genetic Interactions and disease: From genetic predisposition to disease mechanisms (Dr Gavin Hudson) Standard_2025_16: Collagen modifying enzyme COLGALT2 as a mediator of osteoarthritis risk (Dr Sarah Rice) Standard_2025_179: Biomarker-driven risk-stratification of childhood medulloblastoma for improved therapies (Dr Stacey Richardson) Standard_2025_138: The role of nuclear proximity in mitochondrial genetics (Dr Amy Vincent) Standard_2025_78: Investigating regulatory role of transposable elements in human retina during development and aging (Dr Rachel Queen) Standard_2025_108: Discovery of resistance-breaking antibiotics targeting bacterial lipids (Prof Henrik Strahl) Standard_2025_135: Targeting the cytoplasmic regulators of androgen receptor signalling in prostate cancer (Dr Kelly Coffey) Standard_2025_111: Deciphering the impact of DNA damage repair on Staphylococcal infections (Dr Charles Winterhalter) Standard_2025_66: Development of an in vitro co-culture model for the study of upper airway immunity (Dr Jason Powell)

iCASE_2025_11: Synthetic UTRs for mRNA therapeutics (Dr Ian Sudbery) iCASE_2025_27: Understanding how damaged DNA is excised and repaired to maintain genome integrity and prevent cancer (Dr Matthew Newton) iCASE_2025_20: Developing Novel Anti-Inflammatory Agents for Age-Related Diseases (Dr Heather Wilson) Standard_2025_124: Tools to reduce surgical infection: Developing a 3D tissue engineered model of surgical infection and optimisation of skin-facing antimicrobial surgical devices produced through Additive Manufacturing (Joanna Shepherd) Standard_2025_29: Understanding the membrane recruitment of oncogenic KRAS in pancreatic cancer (Dr Helen Matthews) Standard_2025_08: Can frailty be prevented? (Prof Ilaria Bellantuono) Standard_2025_23: Understanding the mechanisms associated with mitochondria dysfunction underpinning both age-related hearing loss and neurodegenerative diseases (Prof Walter Marcotti) Standard_2025_19: Getting to the heart of cardiac infection using zebrafish models (Dr Philip Elks) Standard_2025_36: Digital outcome measures, functional imaging and molecular analysis to mechanistically stratify patients with Parkinson's disease (Prof Oliver Bandmann) Standard_2025_137: Targeting neural–stromal crosstalk in cancer (Prof Fiona Boissonade) Standard_2025_118: Developing new modes of anti-cancer drug delivery using tissue engineered cancer and mass spectrometry imaging (Prof Craig Murdoch) Standard_2025_170: Breaking the wall to finding new drugs for antimicrobial resistant fungi (Dr Simon Johnston) Standard_2025_04: Examining the role of metabolism in paediatric cancer initiation using human pluripotent stem cells (Dr Anestis Tsakiridis) Standard_2025_37: Why do multiple pathogenic viruses including HIV, Influenza, Ebola, Herpesviruses and Adenovirus target a host RNA binding protein? (Prof Stuart Wilson) Standard_2025_80: The Role of Social Isolation and Loneliness in Dementia: Natural Language Processing of Patients’ Electronic Health Records (Dr Nemanja Vaci) Standard_2025_11: A bioelectrical approach to control breast cancer invasion (Dr Alexander Fletcher) Standard_2025_145: A search for pharmacological inhibitors of a cancer-associated adhesion GPCR in the zebrafish embryo (Prof Tanya Whitfield) Standard_2025_200: Tackling ageing in the gut: investigating the contribution of macrophages in the intestinal stem cell niche to gut maintenance and repair (Dr Catarina Henriques) Standard_2025_202: Old-age macrophages? Programming distinct immune behaviours across the lifecourse (Dr Iwan Evans)

iCASE_2025_05: Magnetic Nanoparticles with Elastin-Like Peptide Coating for Delivery of Therapeutic Proteins for Bone Disease Treatment (Prof Victor Chechik) iCASE_2025_19: Nano-drug delivery systems from engineered stem cells (Prof Paul Genever) iCASE_2025_24: Enhancing LNP-RNA delivery to leukemia cells through cutting-edge cryogenic electron tomography (Dr Jamie Blaza) iCASE_2025_30: Exploring cancer transcriptomes with Nanopore long-read sequencing (Prof Dimitris Lagos). Standard_2025_47: Investigating the role and regulation of biomolecular condensate enabling trypanosome parasites host adaptation (Dr Mathieu Cayla) Standard_2025_86: Divide and Conquer: Unravelling how blood cancers take over using state-of-the-art technologies. (Prof David Kent) Standard_2025_164: Understanding cellular mechanisms underlying the autism spectrum disorder Neurofibromatosis type 2 (Dr Ines Hahn) Standard_2025_10: Engineering mosquitoes to provide no-cold-chain delivery of vaccines (Prof Luke Alphey) Standard_2025_102: Skin inflammatory disorders modulate susceptibility to virus infection (Dr Clive McKimmie) Standard_2025_174: Optical methods for biomarker discovery in prostate cancer—cells to circulating cellular components (Dr Yvette Hancock) Standard_2025_95: The impact of a wild lifestyle on age-related immune dysfunction (Dr James Hewitson) Standard_2025_42: Discovering immunoregulatory pathways used by pathogens to identify new immunotherapeutic targets for cancer and autoimmune disease (Prof Gavin Wright) Standard_2025_18: Exploration of Ruthenium Complexes as Potential Candidates against Mycobacteria (Dr Angelo Frei) Standard_2025_98: Investigating attached Leishmania forms and their contribution to human infections (Dr Nicola Baker) Standard_2025_160: The wrong place at the wrong time? The role of TMEM106b trafficking in dementia (Dr Noemie Hamilton) Standard_2025_128: Masters of disguise: Illuminating the regulatory role of SUMOylation in Trypanosome immune evasion (Dr Joana Faria) Standard_2025_67: GAGs, CCL5 and CCR5: elucidating a complex partnership for cancer immunotherapy (Dr Nathalie Signoret) Standard_2025_68: Identifying and imaging pathology in Parkinson’s Disease at cellular, neuronal circuit and behavioural levels (Prof Sean Sweeney) Standard_2025_69: Characterisation of the molecular pathway underlying RNA-binding deficient TDP-43 in neurodegeneration (Dr Han-Jou Chen) Standard_2025_213: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses (Dr Chris Hill)

Yes you must apply to three projects. We recommend you contact the supervisors before submitting your application to discuss their research in more detail and inform your decision. If you are shortlisted to the interview stage, you will be asked to rank projects in order of preference. Not all candidates are offered their first choice of project and you may be offered your second or third choice.

No, you can apply for any combination of 3 projects, regardless of the institution at which these are based.

Yes. You should apply to DiMeN with only one application form - select three projects from the dropdown tool.

Applicants need to meet the English language condition of their offer by the deadline for meeting all offer conditions, which is the 8th September 2025 for applicants that will need to apply for CAS: https://www.sheffield.ac.uk/postgraduate/deadlines

Many of our applicants are studying for an Undergraduate or Masters qualification which is still in progress. Applicants need to meet the condition of their offer by 8th September 2025.

References are not viewed during the shortlisting process. However, if you are selected for interview your references and CV will be made available to your project supervisors and interview panel as part of the selection process. The deadline for uploading references is 25th January 2025.

We will be holding interviews online between 24th and 28th February 2025 and aim to contact shortlisted candidates by 3rd February. We typically receive over 700 applications to DiMeN and therefore it can take some time for non-shortlisted candidates to receive an individual formal rejection. However, we will post more general updates on the DiMeN website during the selection process so please check for new information.

If you are having issues try switching to a different browser such as Chrome. The application portal is managed by the University of Sheffield - please contact our admission team using the chat function on the prospective students page with any queries.

Some projects are feasible part-time, however not all of them due to the specific experimental work commitments and you would need to discuss this as an option with the supervisory team before applying. International students must also consider UK Visas and Immigration (UKVI) restrictions and contact the host university international office for advice. Part-time study can only be at 50% of full time, so our 4 year programme would be spread over 8 years and stipend funding at 50% per payment. This has implications on Council tax as part-time students are no longer exempt. It is possible to switch to part-time during your PhD according to personal circumstances and this is reviewed locally, on a case-by-case basis.

We accept applications from international students, however there is a 30% cap on places for international students on our programme. Fees are covered for international fee status students but candidates are required to meet all visa, healthcare surcharges, and relocation costs. You can find out more about fee status here.