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Leeds Liverpool Newcastle Sheffield

MRC DiMeN Doctoral Training Partnership

Discovery Medicine North

Current Opportunities

Opportunities for October 2018

We are excited to announce a special call for PhD student applications in Artificial Intelligence, Machine Learning and Data Science research.

The DiMeN partnership has new studentship opportunities available in the future focusing on the complementary themes of:

  • Genetic Influences on Health
  • Ageing and Disease
  • Bioinformatics and Personalised Medicine

We put student choice at the heart of our Doctoral Training Partnership, below you will find an amazing range of 38 projects for you to choose for PhD study.  During the application process you will be asked to shortlist three projects to be considered for.  Use the links below to investigate detailed project descriptions and find out more about the supervisory teams.  We actively encourage you to contact lead supervisors to help make this important decision and inform your application.

Project titles (click the links below to view full project abstracts):

Tensor-based machine learning for personalised medicine https://www.findaphd.com/search/ProjectDetails.aspx?PJID=96696  Supervisors: Dr Dennis Wang (Sheffield), Dr Haiping Lu (Sheffield), Non-academic Partner: AstraZeneca

Machine learning methods for assisted living  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97093 Supervisors: Prof  Lyudmila Mihaylova (Sheffield), Prof Fabio Ciravegna (Sheffield), Prof Mark Hawley (Sheffield),

Application of machine learning approaches to analyse big and noisy datasets to understand the host response to lung and tissue damage by toxic agents https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97094 Supervisors: Prof Julian Hiscox (Liverpool), Dr Graeme Clark (Defence Science Technology Laboratory), CASE studentship partner: Defence Science and Technology Laboratory

Deep learning approaches to discover new roles for non-canonical signalling in cancer   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97095  Supervisors: Prof Andy Jones (Liverpool), Prof Claire Eyers (Liverpool)

Big data analytics to understand heritable risk factors in melanoma   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97096  Supervisors: Dr Mark Martin Iles (Leeds), Prof Tim Bishop (Leeds)

Machine learning approaches to prediction and prognosis in haematological cancers   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97097  Supervisors: Prof David Westhead (Leeds), Dr Reuben Tooze (Leeds) Non-academic Partner: Haematological malignancy diagnostic service, St. James's University Hospital, Leeds.

Personlized models of brain stimulation  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97112 Supervisors: Prof Marcus Kaiser (Newcastle), Dr Roman Bauer (Newcastle), Non-academic partner: Soterix Medical (USA)

Socioeconomic deprivation as a determinant of congenital diaphragmatic hernia: a translational, interdisciplinary investigation to inform prevention   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97116 Supervisors: Prof Judith Rankin (Newcastle), Dr Kate Best (Newcastle)

A systems pharmacology approach to better understand variation in statin response using advanced computational methods      https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97124   Supervisors: Professor Sir Munir Pirmohamed (Liverpool), Prof Andrew Morris (Liverpool), Non-academic partner: SAP

A Multi-scale computational model of bone remodelling for preclinical prediction of the effect of musculoskeletal treatments   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97125  Supervisors: Dr Enrico Dall’Ara (Sheffield), Prof Marco Viceconti (Sheffield)

Building integrated computer vision and genomic approaches to quantitate bone quality and fracture risk   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97126   Supervisors: Prof Mark Wilkinson (Sheffield), Prof Alejandro Frangi (Sheffield), Prof Eleftheria Zeggini (Wellcome Sanger Institute), Prof Chris Seal (Newcastle), Dr Dan Cuthbertson (Liverpool)

An individual participant data meta-analysis of early life determinants of obesity: a translational investigation of maternal behavioural and clinical determinants to inform childhood obesity prevention     https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97127  Supervisors: Dr Nicola Heslehurst (Newcastle), Prof Judith Rankin (Newcastle), Prof Paul Burton (Newcastle)

Applying Machine Learning to 3D single molecule localisation analysis in super-resolution microscopy  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97128   Supervisors: Prof Michelle Peckham (Leeds), Dr Joanna Leng (Leeds)

Accelerating super-resolution microscopy with machine learning and pattern recognition  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=93052    Supervisors: Dr Isuru Jayasinghe (Leeds),  Prof Nikita Gamper (Leeds), Dr Joanna Leng (Leeds)

Use of data science to elucidate functional mechanisms of inherited genetic variants of apoptosis genes affecting breast cancer susceptibility  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97129  Supervisors: Prof Angela Cox (Sheffield), Dr Ian Sudbery (Sheffield) 

How do cells “remember” their transcriptional programme after cell division   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97130    Supervisors: Prof Jonathan Higgins (Newcastle), Dr Daniel Rico Rodriguez (Newcastle)

Artificial Intelligence Methods for Drug Discovery   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97131  Supervisors: Dr Caroline Dart (Liverpool), Dr Jonathan Lippiat (Leeds), Dr Jaume Bacardit (Newcastle), Dr Richard Barrett-Jolley (Liverpool)

Inference of the neural drive to muscles using tensor decompositions and single-trial decoding algorithms   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97132 Supervisors: Dr Ioannis Delis (Leeds), Dr Samit Chakrabarty (Leeds)

Application of Machine Learning to Neuronal Phenotypic Models to Identify drug targets in Motor Neuron Disease   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97133  Supervisors: Dr Richard Mead (Sheffield), Dr Dennis Wang (Sheffield)  Non-academic partner: Heptares Therapeutics

Scalable and interpretable machine learning strategies for automated annotation of single-cell RNA-sequencing data   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97134  Supervisors: Prof Muzlifah Haniffa (Newcastle), Dr Jaume Bacardit (Newcastle)

Use of machine learning methods to develop new biomarkers for nutrition induced toxicity  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97135  Supervisors: Prof Georg Lietz (Newcastle), Dr Jaume Bacardit (Newcastle), Prof Matthew Wright (Newcastle), Dr Dina Tiniakos (Newcastle)

Network correlation of non-coding RNAs: A new gene regulatory network in virus infection  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=93057  Supervisors: Prof Adrian Whitehouse (Leeds), Dr Ian Carr (Leeds)

Detection of ultra-low frequency heart rate variability markers of disease using Artificial Intelligence beat detection and HRV modelling https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97136  Supervisors: Dr Richard Barrett-Jolley (Liverpool), Dr Jaume Bacardit (Newcastle), Dr Ingeborg Welters (Liverpool)

Causal Modelling to  investigate ionic motion in neuronal cell networks     https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97137  Supervisors:  Prof Merlyne De Souza (Sheffield), Dr Claire Garwood (Sheffield), Dr Mauricio Álvarez (Sheffield), Prof Visakan Kadirkamanathan (Sheffield) 

Heart Motion Abnormality Detection Using Bayesian Deep Networks     https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97175 Supervisors: Dr Ali Gooya (Sheffield), Prof Alejandro Frangi (Sheffield)

Interpretable machine learning for in-situ healthcare delivery via wearable devices https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97176 Supervisors: Dr George Panoutsos (Sheffield), Dr Iñaki Esnaola (Sheffield), Dr Mann van de Werken (SleepCogni) Non-Academic Partner: SleepCogni

Identifying new drugs to combat the virulence mechanisms underlying multidrug-resistant typhoid https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97182 Supervisors: Dr Daniel Humphreys (Sheffield), Dr Stephen Brown (Sheffield), Prof Stephen Baker (Oxford and Vietnam)

Quantifying and incorporating information bias in modern life science        https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97183  Supervisors: Dr Mirre Simons (Sheffield), Dr Toni Gossmann (Sheffield)

Machine learning analysis of optical coherence tomography images  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97185 Supervisors: Prof J Read (Newcastle), Dr Will Innes (Newcastle), Prof Marcus Kaiser (Newcastle)

Using artificial intelligence to characterise cell-derived collagen scaffolds at the nanoscale https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97186   Supervisors: Dr Nicola Green (Sheffield), Dr Cornelia Rodenburg (Sheffield), Dr Frederik Claeyssens (Sheffield)

Integrating electronic health records and data derived from in silico models, for personalised medicine https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97187  Supervisors: Dr Maria-Cruz Villa-Uriol (Sheffield), Dr Mauricio Álvarez (Sheffield)

Using machine learning to improve outcomes in kidney transplantation   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97188   Supervisors: Prof Andrew Jones (Liverpool), Prof Derek Middleton (Royal Liverpool University Hospital)

Learning the Heart: Machine Learning on Cardiac Imaging Data for Cardiovascular Disease Diagnosis   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97189 Supervisors: Dr Haiping Lu (Sheffield), Dr Andrew Swift (Sheffield), Non-academic partner: GlaxoSmithKline

 

Use of deep neural networks to identify mutational signatures https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97192 Supervisors: Dr Mauro Santibanez Koref (Newcastle), Dr Stephen McGough (Newcastle), Dr Yu Guan (Newcastle), Dr Michael Jackson (Newcastle)

Predicting dynamic response of SUMOylation to stress: a combined modelling and experimental approach  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97193  Supervisors: Dr Chun Guo (Sheffield), Dr Ling-zhong Guo (Sheffield)

Using zebrafish to understand how genetic defects affect neuronal circuits  https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97195 Supervisors: Dr Anton Nikolaev (Sheffield), Dr Vincent Cunliffe (Sheffield)

Artificial Intelligence Technology for Cell Therapy Manufacturing https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97196 Supervisors:  Prof Daniel Coca (Sheffield), Dr Ivana Barbaric (Sheffield)

Evolutionary and thermodynamical features of musculoskeletal disease mutations is human intrinsically disordered protein regions   https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97197 Supervisors: Dr Toni Gossmann (Sheffield), Dr Dan Rigden (Liverpool), Dr Mirre Simons (Sheffield)

 

To apply please carefully read the instructions on the 'application overview' page and use the link on the page to submit an application. 

Any questions regarding the application process or benefits of DiMeN to your PhD experience, please contact the DiMeN DTP manager Emily: dimen.dtp@sheffield.ac.uk 

Good Luck