UK Medical Research Logo Leeds University Logo Liverpool Uni Logo Newcastle Uni Logo Sheffield University Logo UK Medical Research Logo Leeds University Logo Liverpool University Logo Newcastle University Logo Sheffield University Logo
UK Medical Research Logo Leeds University Logo Liverpool Uni Logo Newcastle Uni Logo Sheffield University Logo

Leeds Liverpool Newcastle Sheffield

MRC DiMeN Doctoral Training Partnership

Discovery Medicine North

DiMeN Student Publications

DiMeN Student Publications

 

2020

Bartoli, F., Bailey, M. A., Rode, B., Mateo, P., Antigny, F., Bedouet, K., Gerbaud, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Ainscough, J. F. X., Kearney, M. T., Bruns, A.-F., Shi, J., Appleby, H. L., Young, R. S., Shawer, H. M., Debant, M., Gomez, A.-M., Beech, D. J., Foster, R., Benitah, J.-P. and Sabourin, J. (2020) ‘Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload’, Circulation. doi: 10.1161/CIRCULATIONAHA.118.038891.

 

Devlin, L. A., Ramsbottom, S. A., Overman, L. M., Lisgo, S. N., Clowry, G., Molinari, E., Powell, L., Miles, C. G. and Sayer, J. A. (2020) ‘Embryonic and foetal expression patterns of the ciliopathy gene CEP164’, PLOS ONE, 15(1), p. e0221914. doi: 10.1371/journal.pone.0221914.

 

2019

Ajuwon, V., Ali, S.-E., Ashra, N., Banas, C., Barasa, S., Bhalla, S. R., Chakrabarty, A., Elelu, N., Ha, K. P., Ihekwaba, N., Mirza, N., Said, S., Sarmin, A., Sarveswaran, N., Simon, A. and Vallath, S. (2019) ‘Workforce Diversity: Let’s talk about race’, eLife, 12 April. Available at: https://elifesciences.org/inside-elife/313036d9/workforce-diversity-let-s-talk-about-race.

 

Ali, S.-E., Waddington, J. C., Park, B. K. and Meng, X. (2019) ‘Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury’, Chemical Research in Toxicology. doi: 10.1021/acs.chemrestox.9b00275.

 

Allen, S. P., Hall, B., Castelli, L. M., Francis, L., Woof, R., Siskos, A. P., Kouloura, E., Gray, E., Thompson, A. G., Talbot, K., Higginbottom, A., Myszczynska, M., Allen, C. F., Stopford, M. J., Hemingway, J., Bauer, C. S., Webster, C. P., De Vos, K. J., Turner, M. R., Keun, H. C., Hautbergue, G. M., Ferraiuolo, L. and Shaw, P. J. (2019) ‘Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis’, Brain, 142(3), pp. 586–605. doi: 10.1093/brain/awy353.

 

Allen, S. P., Hall, B., Woof, R., Francis, L., Gatto, N., Shaw, A. C., Myszczynska, M., Hemingway, J., Coldicott, I., Willcock, A., Job, L., Hughes, R. M., Boschian, C., Bayatti, N., Heath, P. R., Bandmann, O., Mortiboys, H., Ferraiuolo, L. and Shaw, P. J. (2019) ‘C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis’, Brain: A Journal of Neurology, 142(12), pp. 3771–3790. doi: 10.1093/brain/awz302.

 

Bennison, D. J., Irving, S. E. and Corrigan, R. M. (2019) ‘The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly’, Cells, 8(11), p. 1313. doi: 10.3390/cells8111313.

 

da Silva, B., Irving, B. K., Polson, E. S., Droop, A., Griffiths, H. B. S., Mathew, R. K., Stead, L. F., Marrison, J., Williams, C., Williams, J., Short, S. C., Scarcia, M., O’Toole, P. J., Allison, S. J., Mavria, G. and Wurdak, H. (2019) ‘Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells’, Journal of Cell Science, 132(19). doi: 10.1242/jcs.228452.

 

Devlin, L. A. and Sayer, J. A. (2019) ‘Renal ciliopathies’, Current Opinion in Genetics & Development. (Molecular and genetic basis of disease), 56, pp. 49–60. doi: 10.1016/j.gde.2019.07.005.

 

Duncan, C. J. A., Thompson, B. J., Chen, R., Rice, G. I., Gothe, F., Young, D. F., Lovell, S. C., Shuttleworth, V. G., Brocklebank, V., Corner, B., Skelton, A. J., Bondet, V., Coxhead, J., Duffy, D., Fourrage, C., Livingston, J. H., Pavaine, J., Cheesman, E., Bitetti, S., Grainger, A., Acres, M., Innes, B. A., Mikulasova, A., Sun, R., Hussain, R., Wright, R., Wynn, R., Zarhrate, M., Zeef, L. A. H., Wood, K., Hughes, S. M., Harris, C. L., Engelhardt, K. R., Crow, Y. J., Randall, R. E., Kavanagh, D., Hambleton, S. and Briggs, T. A. (2019) ‘Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2’, Science Immunology, 4(42). doi: 10.1126/sciimmunol.aav7501.

 

Duncan, J. A., Foster, R. and Kwok, J. C. F. (2019) ‘The potential of memory enhancement through modulation of perineuronal nets’, British Journal of Pharmacology, 176(18), pp. 3611–3621. doi: 10.1111/bph.14672.

 

Hatton, C. F. and Duncan, C. J. A. (2019) ‘Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis’, Frontiers in Immunology, 10. doi: 10.3389/fimmu.2019.02656.

 

Mallett G, Laurence A and Amarnath S (2019) Programmed Cell Deah-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid cells International Journal of Molecular Sciences 20(11) 2836  doi: 10.3390/ijms20112836

 

Manners, O., Baquero-Perez, B. and Whitehouse, A. (2019) ‘m6A: Widespread regulatory control in virus replication’, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. (mRNA modifications in gene expression control), 1862(3), pp. 370–381. doi: 10.1016/j.bbagrm.2018.10.015.

 

Masi A.C., Stewart C.J. (2019) ‘The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis’, Early Hum Dev., 138(104854), pp. 1-5. doi: 10.1016/j.earlhumdev.2019.104854

 

Miles, J., Scherz-Shouval, R. and van Oosten-Hawle, P. (2019) ‘Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response’, Trends in Biochemical Sciences, 44(11), pp. 927–942. doi: 10.1016/j.tibs.2019.06.009.

 

Molinari, E., Ramsbottom, S. A., Srivastava, S., Booth, P., Alkanderi, S., McLafferty, S. M., Devlin, L. A., White, K., Gunay-Aygun, M., Miles, C. G. and Sayer, J. A. (2019) ‘Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts’, Scientific Reports, 9(1), pp. 1–13. doi: 10.1038/s41598-019-47243-z.

 

Powell, L., Samarakoon, Y. H., Ismail, S. and Sayer, J. A. (2019) ‘ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses’, Small GTPases, 0(0), pp. 1–10. doi: 10.1080/21541248.2019.1703466.

 

Ramsbottom, S. A., Thelwall, P. E., Wood, K. M., Clowry, G. J., Devlin, L. A., Silbermann, F., Spiewak, H. L., Shril, S., Molinari, E., Hildebrandt, F., Gunay-Aygun, M., Saunier, S., Cordell, H. J., Sayer, J. A. and Miles, C. G. (2019) ‘Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome’, Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1912602117.

 

Rudman, J., Evans, R. J. and Johnston, S. A. (2019) ‘Are macrophages the heroes or villains during cryptococcosis?’, Fungal Genetics and Biology, 132, p. 103261. doi: 10.1016/j.fgb.2019.103261.

 

Sheard, T. M., Hurley, M. E., Colyer, J., White, E., Norman, R., Pervolaraki, E., Narayanasamy, K. K., Hou, Y., Kirton, H. M. and Yang, Z. (2019) ‘Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy’, ACS nano, 13(2), pp. 2143–2157. doi: 10.1021/acsnano.8b08742.

 

Souilhol, C., Gauci, I., Feng, S., Tardajos Ayllon, B., Mahmoud, M., Canham, L., Fragiadaki, M., Serbanovic-Canic, J., Ridger, V. and Evans, P. C. (2019) ‘Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites’, Cardiovascular Research, cvz235. doi: 10.1093/cvr/cvz235.

 

Wood, A., Irving, S. E., Bennison, D. J. and Corrigan, R. M. (2019) ‘The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus’, PLOS Genetics, 15(8), p. e1008346. doi: 10.1371/journal.pgen.1008346.

 

2018

Adamson, K. I., Sheridan, E. and Grierson, A. J. (2018) ‘Use of zebrafish models to investigate rare human disease’, Journal of Medical Genetics, 55(10), pp. 641–649. doi: 10.1136/jmedgenet-2018-105358.

 

Bansagi, B., Phan, V., Baker, M. R., O’sullivan, J., Jennings, M. J., Whittaker, R. G., Müller, J. S., Duff, J., Griffin, H. and Miller, J. A. (2018) ‘Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation’, Neurology, 90(21), pp. e1842–e1848. doi: 10.1212/WNL.0000000000005566.

 

Bartoli, F., Bailey, M., Rode, B., Mateo, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Gomez, A. M., Beech, D., Foster, R., Benitah, J. P. and Sabourin, J. (2018) ‘Orai1 channels inhibition protects the heart from pressure overload-induced ventricular dysfunction’, Journal of Molecular and Cellular Cardiology. (SI:Abstracts ISHR-ES Amsterdam), 120, p. 12. doi: 10.1016/j.yjmcc.2018.05.046.

 

Boczonadi, V., Jennings, M. J. and Horvath, R. (2018) ‘The role of tRNA synthetases in neurological and neuromuscular disorders’, FEBS Letters, 592(5), pp. 703–717. doi: 10.1002/1873-3468.12962.

  

Juneja, M., Azmi, A., Baets, J., Roos, A., Jennings, M. J., Saveri, P., Pisciotta, C., Bernard-Marissal, N., Schneider, B. L., Verfaillie, C., Chrast, R., Seeman, P., Hahn, A. F., Jonghe, P. de, Maudsley, S., Horvath, R., Pareyson, D. and Timmerman, V. (2018) ‘PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease’, Journal of Neurology, Neurosurgery & Psychiatry, 89(8), pp. 870–878. doi: 10.1136/jnnp-2017-317562.

 

Manners, O., Murphy, J. C., Coleman, A., Hughes, D. J. and Whitehouse, A. (2018) ‘Contribution of the KSHV and EBV lytic cycles to tumourigenesis’, Current Opinion in Virology. (Engineering for viral resistance - Viruses and cancer), 32, pp. 60–70. doi: 10.1016/j.coviro.2018.08.014.

 

Muniyandi, S., Pangratiou, G., Edwards, T. A. and Barr, J. N. (2018) ‘Structure and Function of the Human Respiratory Syncytial Virus M2–1 Protein’, in Harris, J. R. and Bhella, D. (eds) Virus Protein and Nucleoprotein Complexes. Singapore: Springer (Subcellular Biochemistry), pp. 245–260. doi: 10.1007/978-981-10-8456-0_11.

 

Peffers, M. J., Balaskas, P. and Smagul, A. (2018) ‘Osteoarthritis year in review 2017: genetics and epigenetics’, Osteoarthritis and Cartilage, 26(3), pp. 304–311. doi: 10.1016/j.joca.2017.09.009.

 

Ramsbottom, S. A., Molinari, E., Srivastava, S., Silberman, F., Henry, C., Alkanderi, S., Devlin, L. A., White, K., Steel, D. H., Saunier, S., Miles, C. G. and Sayer, J. A. (2018) ‘Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model’, Proceedings of the National Academy of Sciences, 115(49), pp. 12489–12494. doi: 10.1073/pnas.1809432115.

 

Rubaiy, H. N., Ludlow, M. J., Siems, K., Norman, K., Foster, R., Wolf, D., Beutler, J. A. and Beech, D. J. (2018) ‘Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels’, British Journal of Pharmacology, 175(16), pp. 3361–3368. doi: 10.1111/bph.14379.

 

Selvaraj, M., Yegambaram, K., Todd, E. J. A. A., Richard, C.-A., Dods, R. L., Pangratiou, G. M., Trinh, C. H., Moul, S. L., Murphy, J. C., Mankouri, J., Éléouët, J.-F., Barr, J. N. and Edwards, T. A. (2018) ‘The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex’, mBio, 9(6). doi: 10.1128/mBio.01554-18.

 

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F A, Liniany L P, Knight D, Samsel L A, Berlinguer-Palmini R, Yim J J , Felizardo T C, Eckhaus M A, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler D H, Van Kasteren S I, Laurence A, Bogyo M, Watts C, Shevach E M and Amarnath S (2018) PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T cells Immunity 49 (2) 247-263 ; doi: 10.1016/j.immuni.2018.05.006  

 

2017

Allen, C. F., Shaw, P. J. and Ferraiuolo, L. (2017) ‘Can Astrocytes Be a Target for Precision Medicine?’, in El-Khamisy, S. (ed.) Personalised Medicine: Lessons from Neurodegeneration to Cancer. Cham: Springer International Publishing (Advances in Experimental Medicine and Biology), pp. 111–128. doi: 10.1007/978-3-319-60733-7_7.

 

Balaskas, P., Goljanek-Whysall, K., Clegg, P., Fang, Y., Cremers, A., Emans, P., Welting, T. and Peffers, M. (2017) MicroRNA Profiling in Cartilage Ageing, International Journal of Genomics. doi: 10.1155/2017/2713725.

 

Feng, S., Bowden, N., Fragiadaki, M., Souilhol, C., Hsiao, S., Mahmoud, M., Allen, S., Pirri, D., Ayllon Tardajos, B., Akhtar, S., Thompson, A. A. R., Jo, H., Weber, C., Ridger, V., Schober, A. and Evans, P. C. (2017) ‘Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites’, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), pp. 2087–2101. doi: 10.1161/ATVBAHA.117.309249.

 

Marsh, S. A., Arthur, H. M. and Spyridopoulos, I. (2017) ‘The secret life of nonclassical monocytes’, Cytometry Part A, 91(11), pp. 1055–1058. doi: 10.1002/cyto.a.23280.

  

2016

Gleeson, P. J., Wilson, V., Cox, T. E., Sharma, S. D., Smith-Jackson, K., Strain, L., Lappin, D., McHale, T., Kavanagh, D. and Goodship, T. H. J. (2016) ‘Chromosomal rearrangement—A rare cause of complement factor I associated atypical haemolytic uraemic syndrome’, Immunobiology. (SI: XXVI ICW Kanazawa 2016), 221(10), pp. 1124–1130. doi: 10.1016/j.imbio.2016.05.002.

 

Lawrence, H., Deehan, D. J., Holland, J. P., Anjum, S. A., Mawdesley, A. E., Kirby, J. A. and Tyson-Capper, A. J. (2016) ‘Cobalt ions recruit inflammatory cells in vitro through human Toll-like receptor 4’, Biochemistry and Biophysics Reports, 7, pp. 374–378. doi: 10.1016/j.bbrep.2016.07.003.

 

Lawrence, H., Mawdesley, A. E., Holland, J. P., Kirby, J. A., Deehan, D. J. and Tyson-Capper, A. J. (2016) ‘Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation’, Oncotarget, 7(7), pp. 7578–7585. doi: 10.18632/oncotarget.7105.