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MRC DiMeN Doctoral Training Partnership

Discovery Medicine North

DiMeN Student Publications

DiMeN Student Publications



Andrea C Masi, Yaa E A Oppong, Beate Haugk, Christopher A Lamb, Linda Sharp, James M Shaw, Christopher J Stewart, Kofi W Oppong 'Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) formalin fixed paraffin-embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis' - 'Gut' doi:10.1136/gutjnl-2020-322457


James C. Waddington, Serat-E AliSophie L. PenmanPaul WhitakerJane HamlettAmy ChadwickDean J. NaisbittB. Kevin ParkXiaoli Meng 'Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury' - 'Chemical Research in Toxicology' doi:10.1021/acs.chemrestox.0c00400


Alexander G. BuryAmy E. Vincent, Doug M. Turnbull, Paolo Actis, Gavin Hudson 'Mitochondrial Isolation: when size matters' - 'Wellcome Open Research' doi:10.12688/wellcomeopenres.16300.1


Katherine A. Davies, Benjamin Chadwick, Roger Hewson, Juan Fontana, Jamel Mankouri, John N. Barr 'The RNA Replication Site of Tula Orthohantavirus Resides within a Remodelled Golgi Network' - 'Cells' doi:10.3390/cells9071569


Viralkumar V. Panchal, Caitlin Griffiths, Hamed Mosaei, Bohdan Bilyk, Joshua A. F. Sutton, Oliver T. Carnell, David P. Hornby, Jeffrey Green, Jamie K. Hobbs, William L. Kelley, Nikolay Zenkin, Simon J. Foster -  'Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression' - 'Plos Pathogens' doi :10.1371/journal.ppat.1008672


Rebecca Marie Dewhurst, Annachiara Scalzone, Joseph Buckley, Clara Mattu, Kenneth S. Rankin, Piergiorgio Gentile, Ana Marina Ferreira 'Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release' -'Frontier' doi :10.3389/fbioe.2020.00754


Thomas M.D. Sheard, Luke Howlett, Hannah Kirton, Zhaokang Yang, Georgina Gurrola, Derek Steele, Izzy Jayasinghe, Hector H. Valdivia, John Colyer 'Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes' - 'bioRxiv - Preprint Server for Biology': doi: 10.1101/2020.06.26.131854 


Catherine M. Buckley, Henderikus Pots, Aurelie Gueho, James H. Vines, Christopher J. Munn, Ben A. Phillips, Bernd Gilsbach, David Traynor, Anton Nikolaev, Thierry Soldati, Andrew J. Parnell, Arjan Kortholt, and Jason S. King 'Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria' - 'Current Biology': doi:10.1016/j.cub.2020.05.049


Bartoli, F., Bailey, M. A., Rode, B., Mateo, P., Antigny, F., Bedouet, K., Gerbaud, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Ainscough, J. F. X., Kearney, M. T., Bruns, A.-F., Shi, J., Appleby, H. L., Young, R. S., Shawer, H. M., Debant, M., Gomez, A.-M., Beech, D. J., Foster, R., Benitah, J.-P. and Sabourin, J. (2020) ‘Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload’, 'Circulation'. doi: 10.1161/CIRCULATIONAHA.118.038891.


Devlin, L. A., Ramsbottom, S. A., Overman, L. M., Lisgo, S. N., Clowry, G., Molinari, E., Powell, L., Miles, C. G. and Sayer, J. A. (2020) ‘Embryonic and foetal expression patterns of the ciliopathy gene CEP164’, PLOS ONE, 15(1), p. e0221914. doi: 10.1371/journal.pone.0221914.


Matthew J. Burke, Peter G. Stockley, and Joan Boyes. 'Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?', Viruses, 12 doi: 10.3390/v12040473


Andrea C Masi, Sara Koo, Christopher A Lamb ,Mark A Hull, Linda Sharp, Andrew Nelson, James S Hampton, Colin J Rees, Christopher J Stewart. 'Using faecal immunochemical test (FIT) undertaken in a national screening programme for large-scale gut microbiota analysis', GUT. doi:10.1136/gutjnl-2020-321594



Ajuwon, V., Ali, S.-E., Ashra, N., Banas, C., Barasa, S., Bhalla, S. R., Chakrabarty, A., Elelu, N., Ha, K. P., Ihekwaba, N., Mirza, N., Said, S., Sarmin, A., Sarveswaran, N., Simon, A. and Vallath, S. (2019) ‘Workforce Diversity: Let’s talk about race’, eLife, 12 April. Available at:


Ali, S.-E., Waddington, J. C., Park, B. K. and Meng, X. (2019) ‘Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury’, Chemical Research in Toxicology. doi: 10.1021/acs.chemrestox.9b00275.


Allen, S. P., Hall, B., Castelli, L. M., Francis, L., Woof, R., Siskos, A. P., Kouloura, E., Gray, E., Thompson, A. G., Talbot, K., Higginbottom, A., Myszczynska, M., Allen, C. F., Stopford, M. J., Hemingway, J., Bauer, C. S., Webster, C. P., De Vos, K. J., Turner, M. R., Keun, H. C., Hautbergue, G. M., Ferraiuolo, L. and Shaw, P. J. (2019) ‘Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis’, Brain, 142(3), pp. 586–605. doi: 10.1093/brain/awy353.


Allen, S. P., Hall, B., Woof, R., Francis, L., Gatto, N., Shaw, A. C., Myszczynska, M., Hemingway, J., Coldicott, I., Willcock, A., Job, L., Hughes, R. M., Boschian, C., Bayatti, N., Heath, P. R., Bandmann, O., Mortiboys, H., Ferraiuolo, L. and Shaw, P. J. (2019) ‘C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis’, Brain, 142 (12), pp. 3771–3790. doi: 10.1093/brain/awz302.


Bennison, D. J., Irving, S. E. and Corrigan, R. M. (2019) ‘The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly’, Cells, 8(11), p. 1313. doi: 10.3390/cells8111313.


da Silva, B., Irving, B. K., Polson, E. S., Droop, A., Griffiths, H. B. S., Mathew, R. K., Stead, L. F., Marrison, J., Williams, C., Williams, J., Short, S. C., Scarcia, M., O’Toole, P. J., Allison, S. J., Mavria, G. and Wurdak, H. (2019) ‘Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells’, Journal of Cell Science, 132(19). doi: 10.1242/jcs.228452.


Devlin, L. A. and Sayer, J. A. (2019) ‘Renal ciliopathies’, Current Opinion in Genetics & Development. (Molecular and genetic basis of disease), 56, pp. 49–60. doi: 10.1016/j.gde.2019.07.005.


Duncan, C. J. A., Thompson, B. J., Chen, R., Rice, G. I., Gothe, F., Young, D. F., Lovell, S. C., Shuttleworth, V. G., Brocklebank, V., Corner, B., Skelton, A. J., Bondet, V., Coxhead, J., Duffy, D., Fourrage, C., Livingston, J. H., Pavaine, J., Cheesman, E., Bitetti, S., Grainger, A., Acres, M., Innes, B. A., Mikulasova, A., Sun, R., Hussain, R., Wright, R., Wynn, R., Zarhrate, M., Zeef, L. A. H., Wood, K., Hughes, S. M., Harris, C. L., Engelhardt, K. R., Crow, Y. J., Randall, R. E., Kavanagh, D., Hambleton, S. and Briggs, T. A. (2019) ‘Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2’, Science Immunology, 4(42). doi: 10.1126/sciimmunol.aav7501.


Duncan, J. A., Foster, R. and Kwok, J. C. F. (2019) ‘The potential of memory enhancement through modulation of perineuronal nets’, British Journal of Pharmacology, 176(18), pp. 3611–3621. doi: 10.1111/bph.14672.


Hatton, C. F. and Duncan, C. J. A. (2019) ‘Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis’, Frontiers in Immunology, 10. doi: 10.3389/fimmu.2019.02656.


Mallett G, Laurence A and Amarnath S (2019) 'Programmed Cell Deah-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid cells', International Journal of Molecular Sciences 20(11) 2836  doi: 10.3390/ijms20112836


Manners, O., Baquero-Perez, B. and Whitehouse, A. (2019) ‘m6A: Widespread regulatory control in virus replication’, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. (mRNA modifications in gene expression control), 1862(3), pp. 370–381. doi: 10.1016/j.bbagrm.2018.10.015.


Masi A.C., Stewart C.J. (2019) ‘The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis’, Early Hum Dev., 138(104854), pp. 1-5. doi: 10.1016/j.earlhumdev.2019.104854


Miles, J., Scherz-Shouval, R. and van Oosten-Hawle, P. (2019) ‘Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response’, Trends in Biochemical Sciences, 44(11), pp. 927–942. doi: 10.1016/j.tibs.2019.06.009.


Molinari, E., Ramsbottom, S. A., Srivastava, S., Booth, P., Alkanderi, S., McLafferty, S. M., Devlin, L. A., White, K., Gunay-Aygun, M., Miles, C. G. and Sayer, J. A. (2019) ‘Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts’, Scientific Reports, 9(1), pp. 1–13. doi: 10.1038/s41598-019-47243-z.


Powell, L., Samarakoon, Y. H., Ismail, S. and Sayer, J. A. (2019) ‘ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses’, Small GTPases, 0(0), pp. 1–10. doi: 10.1080/21541248.2019.1703466.


Ramsbottom, S. A., Thelwall, P. E., Wood, K. M., Clowry, G. J., Devlin, L. A., Silbermann, F., Spiewak, H. L., Shril, S., Molinari, E., Hildebrandt, F., Gunay-Aygun, M., Saunier, S., Cordell, H. J., Sayer, J. A. and Miles, C. G. (2019) ‘Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome’, Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1912602117.


Rudman, J., Evans, R. J. and Johnston, S. A. (2019) ‘Are macrophages the heroes or villains during cryptococcosis?’, Fungal Genetics and Biology, 132, p. 103261. doi: 10.1016/j.fgb.2019.103261.


Thomas M D Sheard, Miriam E Hurley, John Colyer, Ed White, Ruth Norman, Eleftheria Pervolaraki, Kaarjel K Narayanasamy, Yufeng Hou, Hannah M Kirton, Zhaokang Yang, Liam Hunter, Jung-Uk Shim, Alexander H Clowsley, Andrew J Smith, David Baddeley, Christian Soeller, Michael A Colman, Izzy Jayasinghe 'Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease With Enhanced Expansion Microscopy', ACS Nano, doi: 10.1021/acsnano.8b08742.


Souilhol, C., Gauci, I., Feng, S., Tardajos Ayllon, B., Mahmoud, M., Canham, L., Fragiadaki, M., Serbanovic-Canic, J., Ridger, V. and Evans, P. C. (2019) ‘Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites’, Cardiovascular Research, cvz235. doi: 10.1093/cvr/cvz235.


Wood, A., Irving, S. E., Bennison, D. J. and Corrigan, R. M. (2019) ‘The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus’, PLOS Genetics, 15(8), p. e1008346. doi: 10.1371/journal.pgen.1008346.



Adamson, K. I., Sheridan, E. and Grierson, A. J. (2018) ‘Use of zebrafish models to investigate rare human disease’, Journal of Medical Genetics, 55(10), pp. 641–649. doi: 10.1136/jmedgenet-2018-105358.


Bansagi, B., Phan, V., Baker, M. R., O’sullivan, J., Jennings, M. J., Whittaker, R. G., Müller, J. S., Duff, J., Griffin, H. and Miller, J. A. (2018) ‘Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation’, Neurology, 90(21), pp. e1842–e1848. doi: 10.1212/WNL.0000000000005566.


Bartoli, F., Bailey, M., Rode, B., Mateo, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Gomez, A. M., Beech, D., Foster, R., Benitah, J. P. and Sabourin, J. (2018) ‘Orai1 channels inhibition protects the heart from pressure overload-induced ventricular dysfunction’, Journal of Molecular and Cellular Cardiology. (SI:Abstracts ISHR-ES Amsterdam), 120, p. 12. doi: 10.1016/j.yjmcc.2018.05.046.


Boczonadi, V., Jennings, M. J. and Horvath, R. (2018) ‘The role of tRNA synthetases in neurological and neuromuscular disorders’, FEBS Letters, 592(5), pp. 703–717. doi: 10.1002/1873-3468.12962.


Juneja, M., Azmi, A., Baets, J., Roos, A., Jennings, M. J., Saveri, P., Pisciotta, C., Bernard-Marissal, N., Schneider, B. L., Verfaillie, C., Chrast, R., Seeman, P., Hahn, A. F., Jonghe, P. de, Maudsley, S., Horvath, R., Pareyson, D. and Timmerman, V. (2018) ‘PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease’, Journal of Neurology, Neurosurgery & Psychiatry, 89(8), pp. 870–878. doi: 10.1136/jnnp-2017-317562.


Manners, O., Murphy, J. C., Coleman, A., Hughes, D. J. and Whitehouse, A. (2018) ‘Contribution of the KSHV and EBV lytic cycles to tumourigenesis’, Current Opinion in Virology. (Engineering for viral resistance - Viruses and cancer), 32, pp. 60–70. doi: 10.1016/j.coviro.2018.08.014.


Muniyandi, S., Pangratiou, G., Edwards, T. A. and Barr, J. N. (2018) ‘Structure and Function of the Human Respiratory Syncytial Virus M2–1 Protein’, in Harris, J. R. and Bhella, D. (eds) Virus Protein and Nucleoprotein Complexes. Singapore: Springer (Subcellular Biochemistry), pp. 245–260. doi: 10.1007/978-981-10-8456-0_11.


Peffers, M. J., Balaskas, P. and Smagul, A. (2018) ‘Osteoarthritis year in review 2017: genetics and epigenetics’, Osteoarthritis and Cartilage, 26(3), pp. 304–311. doi: 10.1016/j.joca.2017.09.009.


Ramsbottom, S. A., Molinari, E., Srivastava, S., Silberman, F., Henry, C., Alkanderi, S., Devlin, L. A., White, K., Steel, D. H., Saunier, S., Miles, C. G. and Sayer, J. A. (2018) ‘Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model’, Proceedings of the National Academy of Sciences, 115(49), pp. 12489–12494. doi: 10.1073/pnas.1809432115.


Rubaiy, H. N., Ludlow, M. J., Siems, K., Norman, K., Foster, R., Wolf, D., Beutler, J. A. and Beech, D. J. (2018) ‘Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels’, British Journal of Pharmacology, 175(16), pp. 3361–3368. doi: 10.1111/bph.14379.


Selvaraj, M., Yegambaram, K., Todd, E. J. A. A., Richard, C.-A., Dods, R. L., Pangratiou, G. M., Trinh, C. H., Moul, S. L., Murphy, J. C., Mankouri, J., Éléouët, J.-F., Barr, J. N. and Edwards, T. A. (2018) ‘The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex’, mBio, 9(6). doi: 10.1128/mBio.01554-18.


Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F A, Liniany L P, Knight D, Samsel L A, Berlinguer-Palmini R, Yim J J , Felizardo T C, Eckhaus M A, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler D H, Van Kasteren S I, Laurence A, Bogyo M, Watts C, Shevach E M and Amarnath S (2018) 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T cells' Immunity 49 (2) 247-263 ; doi: 10.1016/j.immuni.2018.05.006  



Allen, C. F., Shaw, P. J. and Ferraiuolo, L. (2017) ‘Can Astrocytes Be a Target for Precision Medicine?’, in El-Khamisy, S. (ed.) Personalised Medicine: Lessons from Neurodegeneration to Cancer. Cham: Springer International Publishing (Advances in Experimental Medicine and Biology), pp. 111–128. doi: 10.1007/978-3-319-60733-7_7.


Balaskas, P., Goljanek-Whysall, K., Clegg, P., Fang, Y., Cremers, A., Emans, P., Welting, T. and Peffers, M. (2017) 'MicroRNA Profiling in Cartilage Ageing', International Journal of Genomics. doi: 10.1155/2017/2713725.


Feng, S., Bowden, N., Fragiadaki, M., Souilhol, C., Hsiao, S., Mahmoud, M., Allen, S., Pirri, D., Ayllon Tardajos, B., Akhtar, S., Thompson, A. A. R., Jo, H., Weber, C., Ridger, V., Schober, A. and Evans, P. C. (2017) ‘Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites’, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), pp. 2087–2101. doi: 10.1161/ATVBAHA.117.309249.


Marsh, S. A., Arthur, H. M. and Spyridopoulos, I. (2017) ‘The secret life of nonclassical monocytes’, Cytometry Part A, 91(11), pp. 1055–1058. doi: 10.1002/cyto.a.23280.



Gleeson, P. J., Wilson, V., Cox, T. E., Sharma, S. D., Smith-Jackson, K., Strain, L., Lappin, D., McHale, T., Kavanagh, D. and Goodship, T. H. J. (2016) ‘Chromosomal rearrangement—A rare cause of complement factor I associated atypical haemolytic uraemic syndrome’, Immunobiology. (SI: XXVI ICW Kanazawa 2016), 221(10), pp. 1124–1130. doi: 10.1016/j.imbio.2016.05.002.


Lawrence, H., Deehan, D. J., Holland, J. P., Anjum, S. A., Mawdesley, A. E., Kirby, J. A. and Tyson-Capper, A. J. (2016) ‘Cobalt ions recruit inflammatory cells in vitro through human Toll-like receptor 4’, Biochemistry and Biophysics Reports, 7, pp. 374–378. doi: 10.1016/j.bbrep.2016.07.003.


Lawrence, H., Mawdesley, A. E., Holland, J. P., Kirby, J. A., Deehan, D. J. and Tyson-Capper, A. J. (2016) ‘Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation’, Oncotarget, 7(7), pp. 7578–7585. doi: 10.18632/oncotarget.7105.